Invasive aspergillosis in a paediatric allogeneic stem cell transplantation recipient owing to a susceptible Aspergillus fumigatus: Treatment failure with high doses of voriconazole and influence of CYP2C19 polymorphisms

Int J Antimicrob Agents. 2016 May;47(5):410-1. doi: 10.1016/j.ijantimicag.2016.02.002. Epub 2016 Feb 27.
No abstract available

Publication types

  • Case Reports
  • Letter

MeSH terms

  • Antifungal Agents / pharmacology
  • Antifungal Agents / therapeutic use*
  • Aspergillus fumigatus / drug effects*
  • Aspergillus fumigatus / isolation & purification
  • Child, Preschool
  • Cytochrome P-450 CYP2C19 / genetics*
  • Humans
  • Invasive Pulmonary Aspergillosis / drug therapy*
  • Invasive Pulmonary Aspergillosis / microbiology
  • Male
  • Polymorphism, Genetic*
  • Stem Cell Transplantation / adverse effects*
  • Transplant Recipients
  • Transplantation, Homologous / adverse effects
  • Treatment Failure
  • Voriconazole / pharmacology
  • Voriconazole / therapeutic use*

Substances

  • Antifungal Agents
  • CYP2C19 protein, human
  • Cytochrome P-450 CYP2C19
  • Voriconazole