Transition-Metal-Free Synthesis of 2-Arylimidazolones via Cascade Reaction between Arynes and α,α'-Disubstituted α-Isocyanoacetamides

Alessandro Gesù; Claudio Pozzoli; Enza Torre; Silvio Aprile; Tracey Pirali

doi:10.1021/acs.orglett.6b00580

Transition-Metal-Free Synthesis of 2-Arylimidazolones via Cascade Reaction between Arynes and α,α'-Disubstituted α-Isocyanoacetamides

Org Lett. 2016 May 6;18(9):1992-5. doi: 10.1021/acs.orglett.6b00580. Epub 2016 Apr 8.

Authors

Alessandro Gesù¹, Claudio Pozzoli¹, Enza Torre¹, Silvio Aprile¹, Tracey Pirali¹

Affiliation

¹ Dipartimento di Scienze del Farmaco, Università degli Studi del Piemonte Orientale "A. Avogadro" , Largo Donegani 2 28100 Novara, Italy.

PMID: 27057924
DOI: 10.1021/acs.orglett.6b00580

Abstract

The reaction between arynes and secondary α,α'-disubstituted α-isocyanoacetamides was developed to access 2-arylimidazolones of structural diversity and complexity in a straightforward manner.

Publication types

Research Support, Non-U.S. Gov't