HLA-A68 and HLA-B15 alleles correlate with poor immune response among AIDS patients on combined antiretroviral therapy

Marah El-Beeli; Samira Hamad Al-Mahrooqi; Randa Mahmoud Youssef; Fahad Zadjali; Abdullah Balkhair; Mohammed Said Al-Balushi; Elias Anthony Said; Sidgi Syed Hasson; Ali Abdullah Al-Jabri

doi:10.1016/j.humimm.2016.04.009

HLA-A68 and HLA-B15 alleles correlate with poor immune response among AIDS patients on combined antiretroviral therapy

Hum Immunol. 2016 Jun;77(6):490-7. doi: 10.1016/j.humimm.2016.04.009. Epub 2016 Apr 8.

Authors

Marah El-Beeli¹, Samira Hamad Al-Mahrooqi², Randa Mahmoud Youssef³, Fahad Zadjali⁴, Abdullah Balkhair⁵, Mohammed Said Al-Balushi⁶, Elias Anthony Said⁷, Sidgi Syed Hasson⁸, Ali Abdullah Al-Jabri⁹

Affiliations

¹ Department of Microbiology and Immunology, College of Medicine and Health Sciences, Sultan Qaboos University, P.O. Box 35, Al Khod, Muscat, Oman. Electronic address: [email protected].
² Department of Microbiology and Immunology, College of Medicine and Health Sciences, Sultan Qaboos University, P.O. Box 35, Al Khod, Muscat, Oman. Electronic address: [email protected].
³ Department of Family Medicine and Public Health, College of Medicine and Health Sciences, Sultan Qaboos University, Muscat, Oman. Electronic address: [email protected].
⁴ Department of Biochemistry, College of Medicine and Health Sciences, Sultan Qaboos University, Muscat, Oman. Electronic address: [email protected].
⁵ Infection Control Unit, Department of Medicine, SQUH, Sultan Qaboos University, P.O. Box 35, Al Khod, Muscat, Oman. Electronic address: [email protected].
⁶ Department of Microbiology and Immunology, College of Medicine and Health Sciences, Sultan Qaboos University, P.O. Box 35, Al Khod, Muscat, Oman. Electronic address: [email protected].
⁷ Department of Microbiology and Immunology, College of Medicine and Health Sciences, Sultan Qaboos University, P.O. Box 35, Al Khod, Muscat, Oman. Electronic address: [email protected].
⁸ Department of Microbiology and Immunology, College of Medicine and Health Sciences, Sultan Qaboos University, P.O. Box 35, Al Khod, Muscat, Oman. Electronic address: [email protected].
⁹ Department of Microbiology and Immunology, College of Medicine and Health Sciences, Sultan Qaboos University, P.O. Box 35, Al Khod, Muscat, Oman. Electronic address: [email protected].

PMID: 27067905
DOI: 10.1016/j.humimm.2016.04.009

Abstract

Around 15-30% of AIDS patients fail to recover their CD4(+) T cell levels following combined antiretroviral therapy despite successful inhibition of HIV-1 replication. The exact reasons for this immune recovery failure are not completely understood. HLA alleles are among the candidate that may explain this failure. A total of 65 adult AIDS patients, with viral load of <50 copies per ml were investigated. Viral load and CD4 T cells counts were performed following standard techniques. HLA genotyping was performed using PCR-SSP technique. The Statistical Package for Social Sciences (SPSS version 19) was used for data processing and analysis. A significantly higher proportion of poor immune responders were carrying HLA-A68 (4.8% compared to 25.0%, P=0.025) and HLA-B15 (2.4% compared to 20.8%, P=0.023). The etiological fraction (Efe%) among carriers of HLA-A68 was 57.89% (95% CI=26.79, 75.79) and was 61.35% (95% CI=35.33, 76.91) among carriers of HLA-B15.

Keywords: AIDS; HIV; HLA; Immune response; Oman; cART.

MeSH terms

Acquired Immunodeficiency Syndrome / drug therapy*
Acquired Immunodeficiency Syndrome / immunology*
Adult
Alleles
Antiretroviral Therapy, Highly Active*
Female
Genetic Association Studies
Genotype
HIV-1*
HLA-A Antigens / genetics*
HLA-B15 Antigen / genetics*
Humans
Immunity, Cellular / genetics*
Male
Middle Aged
Treatment Outcome
Viral Load

Substances

HLA-A Antigens
HLA-B15 Antigen