Preparing (Multi)Fluoroarenes as Building Blocks for Synthesis: Nickel-Catalyzed Borylation of Polyfluoroarenes via C-F Bond Cleavage

Jing Zhou; Maximilian W Kuntze-Fechner; Rüdiger Bertermann; Ursula S D Paul; Johannes H J Berthel; Alexandra Friedrich; Zhenting Du; Todd B Marder; Udo Radius

doi:10.1021/jacs.6b02337

Preparing (Multi)Fluoroarenes as Building Blocks for Synthesis: Nickel-Catalyzed Borylation of Polyfluoroarenes via C-F Bond Cleavage

J Am Chem Soc. 2016 Apr 27;138(16):5250-3. doi: 10.1021/jacs.6b02337. Epub 2016 Apr 18.

Authors

Jing Zhou^{1

2}, Maximilian W Kuntze-Fechner², Rüdiger Bertermann², Ursula S D Paul², Johannes H J Berthel², Alexandra Friedrich², Zhenting Du¹, Todd B Marder², Udo Radius²

Affiliations

¹ College of Science, Northwest A&F University , Yangling, Shaanxi 712100, P. R. China.
² Institut für Anorganische Chemie, Julius-Maximilians-Universität Würzburg , Am Hubland, 97074 Würzburg, Germany.

PMID: 27070867
DOI: 10.1021/jacs.6b02337

Abstract

The [Ni(IMes)2]-catalyzed transformation of fluoroarenes into arylboronic acid pinacol esters via C-F bond activation and transmetalation with bis(pinacolato)diboron (B2pin2) is reported. Various partially fluorinated arenes with different degrees of fluorination were converted into their corresponding boronate esters.

Publication types

Research Support, Non-U.S. Gov't