Abstract
The objective of this study was to examine the effects of NMDAR and AMPAR antagonism on the expression of Zif268 and c-Fos in the hippocampus and medial prefrontal cortex during spatial memory encoding in rats trained in the Morris water maze. NMDAR inhibition impaired navigation and significantly attenuated expression of Zif268, but not c-Fos, in area CA1. AMPAR channel blockade had little effect on learning or IEG expression. Overall, Zif268 and c-Fos displayed markedly different patterns of hippocampal and prefrontal expression, with Zif268 being more closely linked to spatial learning.
Keywords:
Glutamate receptors; Hippocampus; Immediate early genes; Prefrontal cortex; Spatial memory.
Copyright © 2016 Elsevier B.V. All rights reserved.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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6-Cyano-7-nitroquinoxaline-2,3-dione / pharmacology
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Analysis of Variance
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Animals
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Dizocilpine Maleate / pharmacology
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Early Growth Response Protein 1 / metabolism*
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Excitatory Amino Acid Antagonists / pharmacology*
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Gene Expression Regulation / drug effects
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Hippocampus / drug effects*
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Hippocampus / metabolism
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Male
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Maze Learning
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Prefrontal Cortex / drug effects*
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Prefrontal Cortex / metabolism
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Proto-Oncogene Proteins c-fos / metabolism*
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Rats
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Rats, Wistar
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Spatial Learning / drug effects
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Spatial Learning / physiology*
Substances
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Early Growth Response Protein 1
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Egr1 protein, rat
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Excitatory Amino Acid Antagonists
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Proto-Oncogene Proteins c-fos
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Dizocilpine Maleate
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6-Cyano-7-nitroquinoxaline-2,3-dione