Lipid peroxidation in human diseases: evidence of red cell oxidative stress after circulatory shock

G Poli; F Biasi; E Chiarpotto; M U Dianzani; A De Luca; H Esterbauer

doi:10.1016/0891-5849(89)90113-5

Lipid peroxidation in human diseases: evidence of red cell oxidative stress after circulatory shock

Free Radic Biol Med. 1989;6(2):167-70. doi: 10.1016/0891-5849(89)90113-5.

Authors

G Poli¹, F Biasi, E Chiarpotto, M U Dianzani, A De Luca, H Esterbauer

Affiliation

¹ Department of Experimental Medicine and Oncology of the University, Torino, Italy.

PMID: 2707618
DOI: 10.1016/0891-5849(89)90113-5

Abstract

Erythrocytes obtained from human patients with circulatory shock of different aetiology consistently showed a strong increase in lipid peroxidation-derived aldehydes in comparison with red cells of normal adults. The highly toxic compound 4-hydroxynonenal has been recovered exclusively in the erythrocytes of the patients.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adult
Aged
Aged, 80 and over
Aldehydes / blood
Chromatography, High Pressure Liquid
Erythrocytes / metabolism*
Female
Humans
Lipid Peroxidation*
Male
Malondialdehyde / blood
Middle Aged
Oxidation-Reduction
Shock / blood*
Shock, Cardiogenic / blood
Spectrophotometry

Substances

Aldehydes
Malondialdehyde
4-hydroxy-2-nonenal