NLRX1 Helps HIV Avoid a STING Operation

Katrina B Mar; John W Schoggins

doi:10.1016/j.chom.2016.03.011

NLRX1 Helps HIV Avoid a STING Operation

Cell Host Microbe. 2016 Apr 13;19(4):430-1. doi: 10.1016/j.chom.2016.03.011.

Authors

Katrina B Mar¹, John W Schoggins²

Affiliations

¹ Department of Microbiology, University of Texas Southwestern Medical Center, Dallas, TX 75390 USA.
² Department of Microbiology, University of Texas Southwestern Medical Center, Dallas, TX 75390 USA. Electronic address: [email protected].

PMID: 27078064
DOI: 10.1016/j.chom.2016.03.011

Abstract

Immune evasion by HIV-1 during acute infection is critical for the establishment of latency. Barouch et al. (2016) and Guo et al. (2016) demonstrate in independent studies that Nod-like receptor X1 (NLRX1) may facilitate early systemic dissemination of HIV-1 by inhibiting the virus-triggered innate immune response.