Abstract
A gas phase binding study revealed strong intrinsic intermolecular interactions between dianionic halogenated closo-dodecaborates [B12X12](2-) and several neutral organic receptors. Oxidation of a tetrathiafulvalene host allowed switching between two host-guest binding modes in a supramolecular complex. Complexes of β-cyclodextrin with [B12F12](2-) show remarkable stability in the gas phase and were successfully tested as carriers for the delivery of boron clusters into cancer cells.
MeSH terms
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Anions / chemistry
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Binding Sites
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Boron Compounds / chemistry
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Boron Compounds / pharmacology*
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Boron Neutron Capture Therapy
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Cell Line
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Cell Proliferation / drug effects
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Drug Carriers / chemistry
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Drug Delivery Systems
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Heterocyclic Compounds / chemistry*
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Humans
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Hydrophobic and Hydrophilic Interactions
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Molecular Structure
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Neoplasms / drug therapy*
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Neoplasms / pathology
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Oxidation-Reduction
Substances
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Anions
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Boron Compounds
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Drug Carriers
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Heterocyclic Compounds
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dodecaborate
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tetrathiafulvalene