Bugs and Brain: How Infection Makes You Feel Blue

Jasmin Herz; Jonathan Kipnis

doi:10.1016/j.immuni.2016.03.010

Bugs and Brain: How Infection Makes You Feel Blue

Immunity. 2016 Apr 19;44(4):718-20. doi: 10.1016/j.immuni.2016.03.010.

Authors

Jasmin Herz¹, Jonathan Kipnis²

Affiliations

¹ Center for Brain Immunology and Glia (BIG), Department of Neuroscience, School of Medicine, University of Virginia, Charlottesville, VA 22908, USA. Electronic address: [email protected].
² Center for Brain Immunology and Glia (BIG), Department of Neuroscience, School of Medicine, University of Virginia, Charlottesville, VA 22908, USA. Electronic address: [email protected].

PMID: 27096312
DOI: 10.1016/j.immuni.2016.03.010

Abstract

In this issue of Immunity, Prinz and colleagues (2016) describe an unexpected mechanism underlying the role of type I interferon in the initiation of cognitive impairment and sickness behavior during viral infection through induction of chemokine CXCL10 in central nervous system epithelial and endothelial cells.

Publication types

Comment

MeSH terms

Brain / metabolism*
Chemokine CXCL10*
Humans
Virus Diseases

Substances

Chemokine CXCL10