Abstract
Only a few of the genes involved in DNA repair in mammalian cells have been isolated, and induction of a DNA repair gene in response to DNA damage has not yet been established. DNA polymerase beta (beta-polymerase) appears to have a synthetic role in DNA repair after certain types of DNA damage. Here we show that the level of beta-polymerase mRNA is increased in CHO cells after treatment with several DNA-damaging agents.
MeSH terms
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Animals
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Cells, Cultured
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Cricetinae
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Cricetulus
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DNA Damage*
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DNA Polymerase I / biosynthesis
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DNA Polymerase I / genetics*
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Female
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Gene Expression Regulation / drug effects
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Gene Expression Regulation / radiation effects
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Methyl Methanesulfonate
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Methylnitronitrosoguanidine
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Ovary
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RNA, Messenger / biosynthesis
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RNA, Messenger / genetics*
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Ultraviolet Rays
Substances
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RNA, Messenger
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Methylnitronitrosoguanidine
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Methyl Methanesulfonate
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DNA Polymerase I