Advancing Tissue Engineering: A Tale of Nano-, Micro-, and Macroscale Integration

Small. 2016 Apr 27;12(16):2130-45. doi: 10.1002/smll.201501798. Epub 2015 Dec 3.

Abstract

Tissue engineering has the potential to revolutionize the health care industry. Delivering on this promise requires the generation of efficient, controllable and predictable implants. The integration of nano- and microtechnologies into macroscale regenerative biomaterials plays an essential role in the generation of such implants, by enabling spatiotemporal control of the cellular microenvironment. Here we review the role, function and progress of a wide range of nano- and microtechnologies that are driving the advancements in the field of tissue engineering.

Keywords: biomimetics; microenvironments; microfluidics; micromaterials; tissue engineering.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Biocompatible Materials / chemistry*
  • Biotin / chemistry
  • Cellular Microenvironment
  • DNA / chemistry
  • Gels
  • Humans
  • Hydrogels / chemistry
  • Kinetics
  • Microfluidics
  • Microscopy, Electron, Scanning
  • Nanotechnology / methods*
  • Nanotechnology / trends
  • Platelet-Derived Growth Factor / chemistry
  • Regeneration
  • Static Electricity
  • Streptavidin / chemistry
  • Temperature
  • Tissue Engineering / methods*
  • Tissue Engineering / trends
  • Tissue Scaffolds / chemistry
  • Vascular Endothelial Growth Factor A / chemistry
  • Viscosity

Substances

  • Biocompatible Materials
  • Gels
  • Hydrogels
  • Platelet-Derived Growth Factor
  • Vascular Endothelial Growth Factor A
  • Biotin
  • DNA
  • Streptavidin