Abstract
In Denmark, both influenza A(H1N1)pdm09 and influenza B co-circulated in the 2015/16 season. We estimated the vaccine effectiveness (VE) of the trivalent influenza vaccine in patients 65 years and older using the test-negative case-control design. The adjusted VE against influenza A(H1N1)pdm09 was 35.0% (95% confidence interval (CI): 11.1-52.4) and against influenza B 4.1% (95% CI: -22.0 to 24.7). The majority of influenza A(H1N1)pdm09 circulating in 2015/16 belonged to the new genetic subgroup subclade 6B.1.
Keywords:
antigenic characterization; genetic drift; phylogeny; seasonal influenza; vaccine effectiveness.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Aged
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Aged, 80 and over
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Case-Control Studies
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Denmark / epidemiology
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Female
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Humans
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Influenza A Virus, H1N1 Subtype / genetics
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Influenza A Virus, H1N1 Subtype / immunology*
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Influenza A Virus, H1N1 Subtype / isolation & purification
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Influenza Vaccines / administration & dosage*
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Influenza, Human / epidemiology
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Influenza, Human / immunology
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Influenza, Human / prevention & control*
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Influenza, Human / virology
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Male
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Outcome Assessment, Health Care
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Pandemics / prevention & control*
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Seasons
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Sentinel Surveillance
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Vaccination / statistics & numerical data*
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Vaccine Potency*