Abstract
Novel 2'-modified guanosine nucleosides were synthesized from inexpensive starting materials in 7-10 steps via hydroazidation or hydrocyanation reactions of the corresponding 2'-olefin. The antiviral effectiveness of the guanosine nucleosides was evaluated by converting them to the corresponding 5'-O-triphosphates (compounds 38-44) and testing their biochemical inhibitory activity against the wild-type NS5B polymerase.
MeSH terms
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Alkenes / chemical synthesis
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Antiviral Agents / chemical synthesis*
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Azides / chemical synthesis
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Guanine Nucleotides / chemical synthesis*
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Hepacivirus / enzymology
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Nucleic Acid Synthesis Inhibitors / chemical synthesis*
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Viral Nonstructural Proteins / antagonists & inhibitors*
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Viral Nonstructural Proteins / chemistry
Substances
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Alkenes
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Antiviral Agents
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Azides
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Guanine Nucleotides
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Nucleic Acid Synthesis Inhibitors
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Viral Nonstructural Proteins
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NS-5 protein, hepatitis C virus