Embodied neurology: an integrative framework for neurological disorders

Brain. 2016 Jun;139(Pt 6):1855-61. doi: 10.1093/brain/aww076. Epub 2016 Apr 21.

Abstract

From a systems biology perspective, the brain and spinal cord are interwoven with the body: they are ‘embodied’. Freund et al. propose an integrative framework based on biophysical models that aims to characterize neurological disorders and minimize their impact on patients by considering functional interactions between supra-spinal, spinal and peripheral regions simultaneously.

Keywords: biophysical models; dynamic causal modelling; multiscale interactions; neuroimaging; precision neurology.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Central Nervous System / physiopathology*
  • Humans
  • Models, Biological*
  • Nervous System Diseases / diagnostic imaging
  • Nervous System Diseases / pathology*
  • Nervous System Diseases / therapy*
  • Neuroimaging
  • Neurology*