Evidence That Anorectal Transplantation Is the Logical Treatment for Serious Anorectal Dysfunction and Permanent Colostomy

F H Galvao; J Araki; V E Seid; D R Waisberg; M C Traldi; M Naito; B C Araujo; C Lanchotte; E Chaib; L A C D'Albuquerque

doi:10.1016/j.transproceed.2015.10.082

Evidence That Anorectal Transplantation Is the Logical Treatment for Serious Anorectal Dysfunction and Permanent Colostomy

Transplant Proc. 2016 Mar;48(2):497-8. doi: 10.1016/j.transproceed.2015.10.082.

Authors

F H Galvao¹, J Araki², V E Seid³, D R Waisberg³, M C Traldi³, M Naito⁴, B C Araujo³, C Lanchotte³, E Chaib³, L A C D'Albuquerque³

Affiliations

¹ Department of Gastroenterology, University of São Paulo, São Paulo, Brazil. Electronic address: [email protected].
² Department of Plastic Surgery, University of Tokyo, Tokyo, Japan.
³ Department of Gastroenterology, University of São Paulo, São Paulo, Brazil.
⁴ Department of Anatomy Aichi Medical University, Aichi, Japan.

PMID: 27109986
DOI: 10.1016/j.transproceed.2015.10.082

Abstract

Anorectal dysfunction resulting in fecal incontinence or permanent colostomy is a current public health concern that strongly impairs patient quality of life. Present treatment options for this complex disease are expensive and usually ineffective. Anorectal transplantation is the logical treatment for fecal incontinence and permanent colostomy. This procedure has been clinically effective in a few cases reported in the medical literature. Furthermore, experiments in rats, pigs, and dogs have shown promising results, with functional recovery of the graft. In this article we describe the scientific evidence that anorectal transplantation may be an important option for treating anorectal dysfunction.

Publication types

Review

MeSH terms

Animals
Colostomy*
Dogs
Fecal Incontinence / surgery*
Humans
Quality of Life
Rats
Recovery of Function
Rectum / transplantation*
Swine