The next level of 3D tumour models: immunocompetence

Agata Nyga; Joana Neves; Katerina Stamati; Marilena Loizidou; Mark Emberton; Umber Cheema

doi:10.1016/j.drudis.2016.04.010

The next level of 3D tumour models: immunocompetence

Drug Discov Today. 2016 Sep;21(9):1421-1428. doi: 10.1016/j.drudis.2016.04.010. Epub 2016 Apr 22.

Authors

Agata Nyga¹, Joana Neves², Katerina Stamati³, Marilena Loizidou³, Mark Emberton², Umber Cheema⁴

Affiliations

¹ Research Department of Nanotechnology, Division of Surgery and Interventional Science, UCL, London, UK. Electronic address: [email protected].
² Research Department of Urology, Division of Surgery and Interventional Science, UCL, London, UK.
³ Research Department of Nanotechnology, Division of Surgery and Interventional Science, UCL, London, UK.
⁴ Research Department of Materials and Tissues, Institute of Orthopaedics, Division of Surgery and Interventional Science, UCL, London, UK. Electronic address: [email protected].

PMID: 27113911
DOI: 10.1016/j.drudis.2016.04.010

Abstract

The complexity of the tumour microenvironment encompasses interactions between cancer and stromal cells. Moving from 2D cell culture methods into 3D models enables more-accurate investigation of those interactions. Current 3D cancer models focus on cancer spheroid interaction with stromal cells, such as fibroblasts. However, over recent years, the cancer immune environment has been shown to have a major role in tumour progression. This review summarises the state-of-art on immunocompetent 3D cancer models that, in addition to cancer cells, also incorporate immune cells, including monocytes, cancer-associated macrophages, dendritic cells, neutrophils and lymphocytes.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Animals
Cell Culture Techniques
Dendritic Cells / immunology
Humans
Immunocompetence
Leukocytes / immunology
Macrophages / immunology
Models, Biological*
Neoplasms / immunology*

Abstract

Publication types

MeSH terms

Grants and funding