Primary ciliary dyskinesia in two English Cocker Spaniels

E T Bell; P Griffin; P Martinello; P Robinson

doi:10.1111/avj.12418

Primary ciliary dyskinesia in two English Cocker Spaniels

Aust Vet J. 2016 May;94(5):149-153. doi: 10.1111/avj.12418.

Authors

E T Bell¹, P Griffin², P Martinello², P Robinson^{2

3

4}

Affiliations

¹ Translational Research and Animal Clinical Trial Study (TRACTS) Group, Faculty of Veterinary Science, The University of Melbourne, Parkville, Victoria, Australia. [email protected].
² PCD Diagnostic Service, Respiratory Medicine, Royal Children's Hospital, Parkville, Victoria, Australia.
³ Murdoch Children's Research Institute, Royal Children's Hospital, Parkville, Victoria, Australia.
⁴ Department of Paediatrics, The University of Melbourne, Royal Children's Hospital, Parkville, Victoria, Australia.

PMID: 27113985
DOI: 10.1111/avj.12418

Abstract

Background: Primary ciliary dyskinesia (PCD) is an inherited condition characterised by structural and functional defects of ciliated cells. Ciliated cells are present in several different anatomic locations and PCD can thus cause a variety of clinical signs; however, the predominant clinical signs in dogs are respiratory in nature, most commonly chronic nasal discharge and recurrent lower respiratory tract infections commencing in the neonatal period.

Case report and conclusion: This report describes two cases of PCD in English Cocker Spaniel puppies presenting with chronic nasal discharge and bronchopneumonia. We describe the use of a minimally invasive technique to collect samples suitable for cilial studies for its diagnosis.

Keywords: congenital diseases; dogs; respiratory medicine.

Publication types

Case Reports