Dynamic Chiral Nanoparticle Assemblies and Specific Chiroplasmonic Analysis of Cancer Cells

Yuan Zhao; Yaxin Yang; Jing Zhao; Ping Weng; Qingfeng Pang; Qijun Song

doi:10.1002/adma.201600369

Dynamic Chiral Nanoparticle Assemblies and Specific Chiroplasmonic Analysis of Cancer Cells

Adv Mater. 2016 Jun;28(24):4877-83. doi: 10.1002/adma.201600369. Epub 2016 Apr 26.

Authors

Yuan Zhao¹, Yaxin Yang¹, Jing Zhao¹, Ping Weng², Qingfeng Pang², Qijun Song¹

Affiliations

¹ The Key Lab of Food Colloids and Biotechnology, Ministry of Education, School of Chemical and Material Engineering, Jiangnan University, Wuxi, Jiangsu, 214122, P. R. China.
² Wuxi Medical School, Jiangnan University, Wuxi, Jiangsu, 214122, P. R. China.

PMID: 27115447
DOI: 10.1002/adma.201600369

Abstract

Fabricated Ag@Au core-shell nanoparticle (CS NP) assemblies exhibit pronounced and reverse chiral bisignate plasmonic signals spanning 400 to 580 nm, in comparison to Ag NP assemblies. The time-dependent chiro-optical response of assemblies that shift with shell deposition is systematically recorded. Chiral Ag@Au CS NP assemblies first achieve the special discrimination of circulating tumor cells with HER2 overexpression.

Keywords: Ag core; cancer cells; chiroplasmonic analysis; dynamic chirality; shell deposition.

MeSH terms

Cell Line, Tumor
Gold / chemistry
Humans
Metal Nanoparticles / chemistry*
Neoplasms / metabolism*
Neoplasms / pathology*
Receptor, ErbB-2 / analysis*
Receptor, ErbB-2 / metabolism
Silver / chemistry

Substances

Silver
Gold
ERBB2 protein, human
Receptor, ErbB-2