A novel IgA/Delta-like 4/Notch axis induces immunosuppressive activity in human dendritic cells

Clin Immunol. 2016 Jul:168:37-46. doi: 10.1016/j.clim.2016.04.013. Epub 2016 Apr 23.
No abstract available

Keywords: DLL4; IgA; IgG; Myeloid dendritic cells; Notch ligand.

MeSH terms

  • Adaptor Proteins, Signal Transducing
  • Adult
  • Aged
  • CD4-Positive T-Lymphocytes / immunology
  • CD4-Positive T-Lymphocytes / metabolism
  • Calcium-Binding Proteins
  • Coculture Techniques
  • Cytokines / immunology
  • Cytokines / metabolism
  • Dendritic Cells / immunology*
  • Dendritic Cells / metabolism
  • Enzyme-Linked Immunosorbent Assay
  • Female
  • Flow Cytometry
  • Gene Expression / immunology
  • Humans
  • Immunoglobulin A / immunology*
  • Immunoglobulin A / metabolism
  • Immunoglobulin G / immunology
  • Intercellular Signaling Peptides and Proteins / genetics
  • Intercellular Signaling Peptides and Proteins / immunology*
  • Intercellular Signaling Peptides and Proteins / metabolism
  • Male
  • Middle Aged
  • Models, Immunological
  • Receptors, Notch / immunology*
  • Receptors, Notch / metabolism
  • Reverse Transcriptase Polymerase Chain Reaction
  • Rhinitis, Allergic / genetics
  • Rhinitis, Allergic / immunology
  • Rhinitis, Allergic / metabolism
  • Signal Transduction / immunology*
  • Th1 Cells / immunology
  • Th1 Cells / metabolism
  • Th2 Cells / immunology
  • Th2 Cells / metabolism

Substances

  • Adaptor Proteins, Signal Transducing
  • Calcium-Binding Proteins
  • Cytokines
  • DLL4 protein, human
  • Immunoglobulin A
  • Immunoglobulin G
  • Intercellular Signaling Peptides and Proteins
  • Receptors, Notch