Neuroendocrine tumors of the small bowel: evaluation with MR-enterography

Anthony Dohan; Hassan El Fattach; Maxime Barat; Youcef Guerrache; Clarisse Eveno; Raphael Dautry; Sébastien Mulé; Mourad Boudiaf; Christine Hoeffel; Philippe Soyer

doi:10.1016/j.clinimag.2015.12.016

Neuroendocrine tumors of the small bowel: evaluation with MR-enterography

Clin Imaging. 2016 May-Jun;40(3):541-7. doi: 10.1016/j.clinimag.2015.12.016. Epub 2016 Jan 15.

Authors

Affiliations

¹ Department of Body and Interventional Imaging, Hôpital Lariboisière, AP-HP, 2 rue Ambroise Paré, 75475 Paris Cedex 10, France; Université Paris-Diderot, Sorbonne-Paris Cité, 10 rue de Verdun, 75010 Paris, France; UMR INSERM 965, Hôpital Lariboisière, 2 rue Amboise Paré, 75010 Paris, France. Electronic address: [email protected].
² Department of Body and Interventional Imaging, Hôpital Lariboisière, AP-HP, 2 rue Ambroise Paré, 75475 Paris Cedex 10, France. Electronic address: [email protected].
³ Department of Body and Interventional Imaging, Hôpital Lariboisière, AP-HP, 2 rue Ambroise Paré, 75475 Paris Cedex 10, France. Electronic address: [email protected].
⁴ Department of Body and Interventional Imaging, Hôpital Lariboisière, AP-HP, 2 rue Ambroise Paré, 75475 Paris Cedex 10, France. Electronic address: [email protected].
⁵ Université Paris-Diderot, Sorbonne-Paris Cité, 10 rue de Verdun, 75010 Paris, France; UMR INSERM 965, Hôpital Lariboisière, 2 rue Amboise Paré, 75010 Paris, France; Department of Digestive Surgery, Hôpital Lariboisière, AP-HP, 2 rue Ambroise Paré, 75475 Paris cedex 10, France. Electronic address: [email protected].
⁶ Department of Body and Interventional Imaging, Hôpital Lariboisière, AP-HP, 2 rue Ambroise Paré, 75475 Paris Cedex 10, France; Université Paris-Diderot, Sorbonne-Paris Cité, 10 rue de Verdun, 75010 Paris, France. Electronic address: [email protected].
⁷ Department of Radiology, Hôpital Robert Debré, 11 Boulevard Pasteur, 51092 Reims Cedex, France. Electronic address: [email protected].
⁸ Department of Body and Interventional Imaging, Hôpital Lariboisière, AP-HP, 2 rue Ambroise Paré, 75475 Paris Cedex 10, France. Electronic address: [email protected].
⁹ Department of Radiology, Hôpital Robert Debré, 11 Boulevard Pasteur, 51092 Reims Cedex, France. Electronic address: [email protected].
¹⁰ Department of Body and Interventional Imaging, Hôpital Lariboisière, AP-HP, 2 rue Ambroise Paré, 75475 Paris Cedex 10, France; Université Paris-Diderot, Sorbonne-Paris Cité, 10 rue de Verdun, 75010 Paris, France; UMR INSERM 965, Hôpital Lariboisière, 2 rue Amboise Paré, 75010 Paris, France. Electronic address: [email protected].

PMID: 27133701
DOI: 10.1016/j.clinimag.2015.12.016

Abstract

Purpose: To determine the sensitivity of magnetic resonance (MR)-enterography for the detection of neuroendocrine tumors of the small-bowel (NETSB) and analyze the imaging presentation of NETSB on MR-enterography.

Patients & methods: The MR-enterography studies (including HASTE, TruFISP, and 3D VIBE MR sequences before and after intravenous administration of a gadolinium-chelate) of 19 patients with pathologically confirmed NETSB were blindly reviewed. Images were analyzed with respect to imaging presentation. Sensitivity of MR-enterography as well as that of each individual MR-enterography sequence for the diagnosis of NETSB was estimated with 95% confidence intervals (CIs). Comparisons between individual MR-enterography sequences were performed using the McNemar test.

Results: Twenty-seven NETSBs were confirmed in 19 patients. Overall sensitivity of MR-enterography for NETSB detection was 74% (20/27; 95% CI: 54-89%) on a per-lesion basis. On a per-patient basis, MR-enterography had a sensitivity of 95% (18/19; 95% CI: 74-100%) for the detection of NETSB. Best degrees of sensitivity were achieved with 3D VIBE MR-enterography sequences after intravenous administration of a gadolinium-chelate (Se=95%; 18/19) by comparison with HASTE (Se=26%; 5/19) and TruFISP (Se=26%; 5/19) sequences (P=.00022). Visible focal small-bowel mass, mesenteric stranding, and mesenteric mass were found in 16/19 (84%), 17/19 (89%), and 15/19 (79%) patients, respectively.

Conclusion: MR-enterography shows highly suggestive features for the diagnosis of NETSB and has high degrees of sensitivity for the diagnosis of NETSB on a per-patient basis.

Keywords: Intestinal neoplasm; MR-enterography; Neuroendocrine tumor; Small bowel; Small bowel tumor detection.

MeSH terms

Aged
Aged, 80 and over
Contrast Media
Female
Humans
Ileal Neoplasms / diagnostic imaging*
Jejunal Neoplasms / diagnostic imaging*
Magnetic Resonance Imaging* / methods
Male
Middle Aged
Neuroendocrine Tumors / diagnostic imaging*
Retrospective Studies
Sensitivity and Specificity

Substances

Contrast Media