Even Noisy Responses Can Be Perfect If Integrated Properly

John C Doyle

doi:10.1016/j.cels.2016.02.012

Even Noisy Responses Can Be Perfect If Integrated Properly

Cell Syst. 2016 Feb 24;2(2):73-5. doi: 10.1016/j.cels.2016.02.012. Epub 2016 Feb 24.

Author

John C Doyle¹

Affiliation

¹ Computing and Mathematical Sciences, Electrical Engineering, and Bioengineering, California Institute of Technology, Pasadena, CA 91125, USA. Electronic address: [email protected].

PMID: 27135162
DOI: 10.1016/j.cels.2016.02.012

Abstract

Integral feedback for perfect adaptation is a ubiquitous strategy in engineering and biology. Long studied in deterministic settings, it can now be understood in the context of the fully stochastic systems that are prevalent in biology.

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MeSH terms

Adaptation, Physiological*
Engineering
Feedback*
Models, Biological
Stochastic Processes
Systems Biology