PD-1 Shapes B Cells as Evildoers in the Tumor Microenvironment

Cancer Discov. 2016 May;6(5):477-8. doi: 10.1158/2159-8290.CD-16-0307.

Abstract

Protumorigenic PD-1(hi) B cells, induced in hepatocellular carcinoma, suppress tumor-specific T-cell response via IL10-dependent pathways upon PD-1/PD-L1 interaction. Anti-PD-1 or anti-PD-L1 antibodies may function not only through blocking the PD-1 coinhibitory pathway in T cells but also via abolishing the suppressive function of regulatory B cells. Cancer Discov; 6(5); 477-8. ©2016 AACRSee related article by Xiao et al., p. 546.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • B-Lymphocytes / metabolism
  • B7-H1 Antigen / immunology*
  • Humans
  • Liver Neoplasms
  • Programmed Cell Death 1 Receptor / antagonists & inhibitors
  • T-Lymphocytes / immunology
  • Tumor Microenvironment / immunology*

Substances

  • B7-H1 Antigen
  • Programmed Cell Death 1 Receptor