A regional approach for CAR T-cell therapy for mesothelioma: from mouse models to clinical trial

Immunotherapy. 2016 May;8(5):491-4. doi: 10.2217/imt-2016-0008.

Authors

Marissa Mayor¹, Masha Zeltsman¹, Erin McGee¹, Prasad S Adusumilli^{1

2}

Affiliations

¹ Thoracic Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
² Center for Cell Engineering, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

PMID: 27140404
DOI: 10.2217/imt-2016-0008

No abstract available

Keywords: adoptive T-cell therapy; chimeric antigen receptor; mesothelin.

Publication types

Editorial
Research Support, Non-U.S. Gov't

MeSH terms

Animals
Antigens, Neoplasm / immunology*
Cell Movement
Disease Models, Animal
GPI-Linked Proteins / immunology*
Genetic Engineering
Humans
Immunotherapy, Adoptive / methods*
Mesothelin
Mesothelioma / immunology
Mesothelioma / therapy*
Mice
Pleural Neoplasms / immunology
Pleural Neoplasms / therapy*
Receptors, Antigen, T-Cell / genetics
Receptors, Antigen, T-Cell / metabolism
Receptors, Lymphocyte Homing / metabolism
Recombinant Fusion Proteins / genetics
Recombinant Fusion Proteins / metabolism
T-Lymphocytes / immunology*
T-Lymphocytes / transplantation

Substances

Antigens, Neoplasm
GPI-Linked Proteins
Msln protein, mouse
Receptors, Antigen, T-Cell
Receptors, Lymphocyte Homing
Recombinant Fusion Proteins
Mesothelin