POLE proofreading mutation, immune response and prognosis in endometrial cancer

Inge C van Gool; Tjalling Bosse; David N Church

doi:10.1080/2162402X.2015.1072675

POLE proofreading mutation, immune response and prognosis in endometrial cancer

Oncoimmunology. 2015 Aug 12;5(3):e1072675. doi: 10.1080/2162402X.2015.1072675. eCollection 2016 Mar.

Authors

Inge C van Gool¹, Tjalling Bosse¹, David N Church²

Affiliations

¹ Department of Pathology, Leiden University Medical Center , Leiden, the Netherlands.
² Molecular and Population Genetics Laboratory, The Wellcome Trust Centre for Human Genetics, University of Oxford , Oxford, UK.

Abstract

Endometrial cancers (ECs) with POLE proofreading mutations are typified by ultramutation and excellent prognosis. We investigated whether these were related, and found that POLE-mutant ECs display a robust T cell response that corresponds to an enrichment of antigenic tumor neopeptides. Enhanced immunogenicity may explain the favorable outcome of POLE-mutant ECs.

Keywords: DNA polymerase ε; POLE; neopeptide; ultramutation.