TGF-β Pathway Inhibition Signals New Hope for Fanconi Anemia

Hemanth Tummala; Inderjeet Dokal

doi:10.1016/j.stem.2016.04.008

TGF-β Pathway Inhibition Signals New Hope for Fanconi Anemia

Cell Stem Cell. 2016 May 5;18(5):567-8. doi: 10.1016/j.stem.2016.04.008.

Authors

Hemanth Tummala¹, Inderjeet Dokal²

Affiliations

¹ Centre for Genomics and Child Health, Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London and Barts Health, London, E12AT, UK.
² Centre for Genomics and Child Health, Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London and Barts Health, London, E12AT, UK. Electronic address: [email protected].

PMID: 27152440
DOI: 10.1016/j.stem.2016.04.008

Abstract

An improved understanding of the bone marrow failure (BMF) mechanisms in Fanconi anemia (FA) may improve current therapeutic strategies. Zhang et al. identify hyperactive TGF-β signaling as an underlying cause of BMF in FA mice and patient cells, whose inhibition promotes DNA repair and hematopoietic stem and progenitor cell survival.

MeSH terms

Animals
DNA Repair
Fanconi Anemia / metabolism*
Humans
Models, Biological
Signal Transduction*
Transforming Growth Factor beta / metabolism*

Substances

Transforming Growth Factor beta