Multimodality Imaging Review of Malignant Pleural Mesothelioma Diagnosis and Staging

Victor H Gerbaudo; Sharyn I Katz; Anna K Nowak; Roslyn J Francis

doi:10.1016/j.cpet.2011.04.001

Multimodality Imaging Review of Malignant Pleural Mesothelioma Diagnosis and Staging

PET Clin. 2011 Jul;6(3):275-97. doi: 10.1016/j.cpet.2011.04.001. Epub 2011 Jun 14.

Authors

Victor H Gerbaudo¹, Sharyn I Katz², Anna K Nowak³, Roslyn J Francis⁴

Affiliations

¹ Division of Nuclear Medicine and Molecular Imaging, Department of Radiology, Harvard Medical School, Brigham & Women's Hospital, 75 Francis Street, Boston, MA 02115, USA.
² Department of Radiology, Hospital of the University of Pennsylvania, University of Pennsylvania School of Medicine, 1 Silverstein Building, 3400 Spruce Street, Philadelphia, PA 19104, USA.
³ Department of Medical Oncology, School of Medicine and Pharmacology, University of Western Australia, Sir Charles Gairdner Hospital, Hospital Avenue, Nedlands 6009, Western Australia, Australia.
⁴ Department of Medical Oncology, School of Medicine and Pharmacology, University of Western Australia, Sir Charles Gairdner Hospital, Hospital Avenue, Nedlands 6009, Western Australia, Australia; Department of Molecular Imaging, School of Medicine and Pharmacology, University of Western Australia, Sir Charles Gairdner Hospital, Hospital Avenue, Nedlands 6009, Western Australia, Australia.

PMID: 27156724
DOI: 10.1016/j.cpet.2011.04.001

Abstract

Early diagnosis and accurate disease staging in patients with malignant pleural mesothelioma (MPM) are essential in classifying such patients into prognostic subgroups to allow delivery of stage-specific therapies. This review addresses the current status of multimodality imaging in the diagnosis and staging of MPM. Clinical, research, and future directions in computed tomography (CT), magnetic resonance imaging, and PET/CT diagnosis and staging of MPM are discussed, including the use of novel PET probes. The article concludes with important take-home messages summarized as the pearls and pitfalls of each diagnostic modality in the diagnosis and staging of patients with MPM.