bcTol : a highly water-soluble biradical for efficient dynamic nuclear polarization of biomolecules

Chem Commun (Camb). 2016 May 19;52(43):7020-3. doi: 10.1039/c6cc01813k.

Abstract

Dynamic nuclear polarization (DNP) is an efficient method to overcome the inherent low sensitivity of magic-angle spinning (MAS) solid-state NMR. We report a new polarizing agent (), designed for biological applications, that yielded an enhancement value of 244 in a microcrystalline SH3 domain sample at 110 K.

MeSH terms

  • Channelrhodopsins / chemistry*
  • Free Radicals / chemical synthesis
  • Free Radicals / chemistry*
  • Magnetic Resonance Spectroscopy
  • Proline / chemistry*
  • Signal-To-Noise Ratio
  • Solubility
  • Spectrin / chemistry*
  • Temperature
  • src Homology Domains

Substances

  • Channelrhodopsins
  • Free Radicals
  • Spectrin
  • Proline