Protein-Nanoreactor-Assisted Synthesis of Semiconductor Nanocrystals for Efficient Cancer Theranostics

Tao Yang; Yong Wang; Hengte Ke; Qiaoli Wang; Xiaoyan Lv; Hong Wu; Yongan Tang; Xiangliang Yang; Chunying Chen; Yuliang Zhao; Huabing Chen

doi:10.1002/adma.201506119

Protein-Nanoreactor-Assisted Synthesis of Semiconductor Nanocrystals for Efficient Cancer Theranostics

Adv Mater. 2016 Jul;28(28):5923-30. doi: 10.1002/adma.201506119. Epub 2016 May 11.

Authors

Tao Yang¹, Yong Wang², Hengte Ke¹, Qiaoli Wang¹, Xiaoyan Lv¹, Hong Wu³, Yongan Tang⁴, Xiangliang Yang⁴, Chunying Chen⁵, Yuliang Zhao⁵, Huabing Chen^{1

2}

Affiliations

¹ Jiangsu Key Laboratory of Translational Research and Therapy for Neuro-Psycho-Diseases, College of Pharmaceutical Sciences, Soochow University, Suzhou, 215123, China.
² School of Radiological and Interdisciplinary Sciences (RAD-X), Collaborative Innovation Center of Radiation Medicineof Jiangsu Higher Education Institutions and School of Radiation Medicine and Protection, Soochow University, Suzhou, 215123, China.
³ School of Pharmacy, Fourth Military Medical University, Xi'an, 710032, China.
⁴ National Engineering Research Center for Nanomedicine and College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, 430074, China.
⁵ CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology of China, Beijing, 100190, China.

PMID: 27165472
DOI: 10.1002/adma.201506119

Abstract

Transition metal sulfide nanocrystals are developed as a theranostic platform through the protein-nanoreactor approach with facile functionalization for multimodal NIRF/PA/SPECT/CT imaging and photothermal tumor ablation.

Keywords: multimodal imaging; photothermal therapy; protein nanoreactors; semiconductor nanocrystals; tumor ablation.

MeSH terms

Humans
Multimodal Imaging
Neoplasms / diagnostic imaging*
Neoplasms / therapy*
Proteins / metabolism*
Quantum Dots*
Theranostic Nanomedicine*

Substances

Proteins