Endothelial Barrier and Metabolism: New Kids on the Block Regulating Bone Marrow Vascular Niches

Ulrike Harjes; Catherine Verfaillie; Peter Carmeliet

doi:10.1016/j.devcel.2016.04.016

Endothelial Barrier and Metabolism: New Kids on the Block Regulating Bone Marrow Vascular Niches

Dev Cell. 2016 May 9;37(3):210-2. doi: 10.1016/j.devcel.2016.04.016.

Authors

Ulrike Harjes¹, Catherine Verfaillie², Peter Carmeliet³

Affiliations

¹ Laboratory of Angiogenesis and Vascular Metabolism, Vesalius Research Center, VIB, Department of Oncology, University of Leuven, 3000 Leuven, Belgium.
² Stem Cell Biology and Embryology Unit, Department of Development and Regeneration, University of Leuven, 3000 Leuven, Belgium.
³ Laboratory of Angiogenesis and Vascular Metabolism, Vesalius Research Center, VIB, Department of Oncology, University of Leuven, 3000 Leuven, Belgium. Electronic address: [email protected].

PMID: 27165553
DOI: 10.1016/j.devcel.2016.04.016

Abstract

The vasculature of the bone marrow remains poorly characterized, yet crucial to maintain hematopoiesis and retain stem cells in a quiescent state. A recent study by Itkin et al. (2016) in Nature reports how vascular barrier integrity and endothelial cell metabolism regulate hematopoietic stem cell quiescence and leukocyte trafficking.

MeSH terms

Animals
Blood Vessels / metabolism
Bone Marrow / metabolism*
Capillary Permeability
Endothelial Cells / metabolism*
Hematopoietic Stem Cells / cytology
Hematopoietic Stem Cells / metabolism
Humans
Stem Cell Niche*