Coordinated Tumor Suppression by Chromosome 8p

Darjus F Tschaharganeh; Benedikt Bosbach; Scott W Lowe

doi:10.1016/j.ccell.2016.04.011

Coordinated Tumor Suppression by Chromosome 8p

Cancer Cell. 2016 May 9;29(5):617-619. doi: 10.1016/j.ccell.2016.04.011.

Authors

Darjus F Tschaharganeh¹, Benedikt Bosbach¹, Scott W Lowe²

Affiliations

¹ Department of Cancer Biology & Genetics, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
² Department of Cancer Biology & Genetics, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Howard Hughes Medical Institute, New York, NY 10065, USA. Electronic address: [email protected].

Abstract

In this issue of Cancer Cell, Cai et al. use genome editing to study 8p deletions in a mammary epithelial cell model and show that 8p loss of heterozygosity (LOH) attenuates the action of several genes that collectively promote cell invasion and enhance cellular sensitivity to autophagy inhibitors.

Publication types

Comment

MeSH terms

Chromosome Deletion*
Chromosome Mapping
Genes, Tumor Suppressor
Humans
Loss of Heterozygosity*
Neoplasms / genetics

Abstract

Publication types

MeSH terms

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