Abstract
The majority of bacteria found within the gut are commensals, although it is unclear whether these organisms can elicit systemic immunity. New research indicates that gut-microbiota-specific serum antibodies targeting an epitope conserved among Gram-negative bacteria can protect the host from systemic pathogenic infection.
Published by Elsevier Ltd.
MeSH terms
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Animals
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Antibodies, Bacterial / immunology*
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Antibody Specificity
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Bacterial Infections / immunology
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Epitopes
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Gastrointestinal Microbiome / immunology*
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Gastrointestinal Microbiome / physiology*
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Gram-Negative Bacteria / classification*
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Gram-Negative Bacteria / genetics
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Gram-Negative Bacteria / immunology*
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Mice
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Mice, Knockout
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Toll-Like Receptors
Substances
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Antibodies, Bacterial
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Epitopes
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Toll-Like Receptors