High T Gives β Cells a Boost

Matthew Wortham; Maike Sander

doi:10.1016/j.cmet.2016.04.015

High T Gives β Cells a Boost

Cell Metab. 2016 May 10;23(5):761-3. doi: 10.1016/j.cmet.2016.04.015.

Authors

Matthew Wortham¹, Maike Sander²

Affiliations

¹ Departments of Pediatrics and Cellular & Molecular Medicine, Pediatric Diabetes Research Center, University of California San Diego, La Jolla, CA 92093-0695, USA.
² Departments of Pediatrics and Cellular & Molecular Medicine, Pediatric Diabetes Research Center, University of California San Diego, La Jolla, CA 92093-0695, USA. Electronic address: [email protected].

PMID: 27166938
DOI: 10.1016/j.cmet.2016.04.015

Abstract

Androgen deficiency in men is associated with metabolic syndrome and diabetes, which has been attributed to actions of androgens upon insulin target tissues. In this issue of Cell Metabolism, Navarro et al. (2016) report a role for androgens and their receptor in the regulation of insulin secretion in β cells.

MeSH terms

Animals
Humans
Insulin / metabolism
Insulin-Secreting Cells / drug effects
Insulin-Secreting Cells / metabolism*
Male
Mice
Models, Biological
Receptors, Androgen / metabolism
Receptors, Cell Surface / metabolism
Signal Transduction / drug effects
Testosterone / pharmacology*

Substances

Insulin
Receptors, Androgen
Receptors, Cell Surface
Testosterone