Identification of a germline F692L drug resistance variant in cis with Flt3-internal tandem duplication in knock-in mice

Haematologica. 2016 Aug;101(8):e328-31. doi: 10.3324/haematol.2016.146159. Epub 2016 May 12.

¹ The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge, UK [email protected] [email protected].
² Department of Medical Genetics, School of Basic Medicine, Peking Union Medical College, Beijing, China State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Beijing, China Department of Haematology, Cambridge University Hospitals NHS Trust, UK.
³ The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge, UK.
⁴ The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge, UK School of Pathology and Laboratory Medicine, University of Western Australia, Crawley, Australia PathWest Division of Clinical Pathology, Queen Elizabeth II Medical Centre, Nedlands, Australia.
⁵ Takeda Pharmaceuticals International, Cambridge, MA, USA.
⁶ Instituto de Biomedicina y Biotecnología de Cantabria, Santander, Spain.
⁷ Department of Medical Genetics, School of Basic Medicine, Peking Union Medical College, Beijing, China State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Beijing, China.
⁸ The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge, UK Department of Haematology, Cambridge University Hospitals NHS Trust, UK [email protected] [email protected].

No abstract available

Keywords: acute myeloid leukemia; molecular pharmacology; tyrosine kinase inhibitor resistance.

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