Human papillomavirus promotes Epstein-Barr virus maintenance and lytic reactivation in immortalized oral keratinocytes

Virology. 2016 Aug:495:52-62. doi: 10.1016/j.virol.2016.05.005. Epub 2016 May 11.

Abstract

Epstein-Barr virus and human papillomaviruses are human tumor viruses that infect and replicate in upper aerodigestive tract epithelia and cause head and neck cancers. The productive phases of both viruses are tied to stratified epithelia highlighting the possibility that these viruses may affect each other's life cycles. Our lab has established an in vitro model system to test the effects of EBV and HPV co-infection in stratified squamous oral epithelial cells. Our results indicate that HPV increases maintenance of the EBV genome in the co-infected cells and promotes lytic reactivation of EBV in upper layers of stratified epithelium. Expression of the HPV oncogenes E6 and E7 were found to be necessary and sufficient to account for HPV-mediated lytic reactivation of EBV. Our findings indicate that HPV increases the capacity of epithelial cells to support the EBV life cycle, which could in turn increase EBV-mediated pathogenesis in the oral cavity.

Keywords: E6; E7; EBV; HPV; Latency; Life-Cycle; Lytic; Organotypic culture.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Cell Line, Transformed
  • Cells, Cultured
  • Herpesvirus 4, Human / physiology*
  • Humans
  • Keratinocytes / virology*
  • Mouth Mucosa / virology
  • Oncogene Proteins, Viral / metabolism
  • Papillomaviridae / classification
  • Papillomaviridae / physiology*
  • Symbiosis*
  • Tissue Culture Techniques
  • Virus Activation
  • Virus Latency
  • Virus Replication

Substances

  • Oncogene Proteins, Viral