Prediction of outcome by lymph node ratio in patients with parotid gland cancer

M F Meyer; M Kreppel; J Meinrath; I Grünewald; M Stenner; U Drebber; A Quaas; M Odenthal; R Semrau; C U Huebbers; J Zöller; K-B Huettenbrink; R Buettner; D Beutner

doi:10.1111/coa.12672

Prediction of outcome by lymph node ratio in patients with parotid gland cancer

Clin Otolaryngol. 2017 Feb;42(1):98-103. doi: 10.1111/coa.12672. Epub 2016 May 30.

Authors

M F Meyer¹, M Kreppel², J Meinrath³, I Grünewald³, M Stenner¹, U Drebber³, A Quaas³, M Odenthal³, R Semrau⁴, C U Huebbers⁵, J Zöller², K-B Huettenbrink¹, R Buettner³, D Beutner¹

Affiliations

¹ Department of Otorhinolaryngology, Head and Neck Surgery, University of Cologne, Cologne, Germany.
² Department for Oral and Maxillofacial Plastic Surgery, University of Cologne, Cologne, Germany.
³ Department of Pathology, University of Cologne, Cologne, Germany.
⁴ Department of Radiation Oncology, University of Cologne, Cologne, Germany.
⁵ Jean-Uhrmacher Institute, University of Cologne, Cologne, Germany.

PMID: 27185037
DOI: 10.1111/coa.12672

Abstract

Objective: Lymph node ratio (LNR) has been shown to be an independent predictor of recurrence risk and survival in different entities of carcinoma.

Methods: In this retrospective chart review, 128 patients with parotid gland cancer (PGC) subsequently treated by primary surgery were included. About 64% (n = 82) of these patients were additionally treated with adjuvant radiotherapy. Five-year overall survival rates were determined by subgroups based on LNR value.

Results: Lymph node ratio was found to be significantly associated with overall survival rate (P < 0.001). Using univariate analyses, pathological tumour-node-metastasis (TNM)-stage, UICC-stage grouping and extracapsular spread were found to be significant predictors of overall survival (P < 0.001). However, with a multivariate analyses, LNR remained the only independent predictor of overall survival (P = 0.043).

Conclusions: After surgery for PGC, evaluation of the neck using LNR was found to reliably stratify the overall survival rate.

MeSH terms

Adolescent
Adult
Aged
Aged, 80 and over
Carcinoma / mortality
Carcinoma / pathology*
Carcinoma / surgery*
Female
Humans
Lymph Node Excision*
Lymph Nodes / pathology*
Male
Middle Aged
Neoplasm Staging
Parotid Neoplasms / mortality
Parotid Neoplasms / pathology*
Parotid Neoplasms / surgery*
Predictive Value of Tests
Retrospective Studies
Survival Rate
Young Adult