Change in the selection of microRNA strands during DNA damage induction

V A Tarasov; M A Makhotkin; E F Shin; N V Boiko; M G Tyutyakina; I E Chikunov; A V Naboka; A N Mashkarina; A A Kirpii; D G Matishov

doi:10.1134/S160767291602006X

Change in the selection of microRNA strands during DNA damage induction

Dokl Biochem Biophys. 2016 Mar;467(1):99-101. doi: 10.1134/S160767291602006X. Epub 2016 May 20.

Authors

Affiliations

¹ Institute of Arid Zones, Southern Scientific Center, Russian Academy of Sciences, pr. Chekhova 41, Rostov-on-Don, 3444006, Russia.
² Institute of Arid Zones, Southern Scientific Center, Russian Academy of Sciences, pr. Chekhova 41, Rostov-on-Don, 3444006, Russia. [email protected].
³ InterLabService Ltd., Moscow, Russia.

PMID: 27193708
DOI: 10.1134/S160767291602006X

Abstract

It was first shown that DNA damage induction in mitomycin C-treated HeLa cells leads to a change in the selection of 5p and 3p microRNA duplex strands in the formation of the RNA-induced silencing complex (RISC).

MeSH terms

DNA Damage / drug effects
DNA Damage / genetics*
DNA Damage / physiology*
HeLa Cells
Humans
MicroRNAs / genetics*
MicroRNAs / metabolism*
Mitomycin / toxicity
Nucleic Acid Synthesis Inhibitors / toxicity
RNA-Induced Silencing Complex / drug effects
RNA-Induced Silencing Complex / genetics
RNA-Induced Silencing Complex / metabolism

Substances

MicroRNAs
Nucleic Acid Synthesis Inhibitors
RNA-Induced Silencing Complex
Mitomycin