Transfer of Two-Dimensional Oligonucleotide Patterns onto Stereocontrolled Plasmonic Nanostructures through DNA-Origami-Based Nanoimprinting Lithography

Yinan Zhang; Jie Chao; Huajie Liu; Fei Wang; Shao Su; Bing Liu; Lan Zhang; Jiye Shi; Lihua Wang; Wei Huang; Lianhui Wang; Chunhai Fan

doi:10.1002/anie.201512022

Transfer of Two-Dimensional Oligonucleotide Patterns onto Stereocontrolled Plasmonic Nanostructures through DNA-Origami-Based Nanoimprinting Lithography

Angew Chem Int Ed Engl. 2016 Jul 4;55(28):8036-40. doi: 10.1002/anie.201512022. Epub 2016 May 19.

Authors

Yinan Zhang^{1

2}, Jie Chao¹, Huajie Liu³, Fei Wang², Shao Su¹, Bing Liu², Lan Zhang², Jiye Shi^{4

5}, Lihua Wang², Wei Huang¹, Lianhui Wang⁶, Chunhai Fan⁷

Affiliations

¹ Key Laboratory for Organic Electronics & Information Displays (KLOEID), Institute of Advanced Materials (IAM) and School of Materials Science and Engineering, Nanjing University of Posts & Telecommunications Institution, 9 Wenyuan Road, Nanjing, 210046, China.
² Division of Physical Biology and Bioimaging Center, Shanghai Synchrotron Radiation Facility, CAS Key Laboratory of Interfacial Physics and Technology, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai, 201800, China.
³ Division of Physical Biology and Bioimaging Center, Shanghai Synchrotron Radiation Facility, CAS Key Laboratory of Interfacial Physics and Technology, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai, 201800, China. [email protected].
⁴ Kellogg College, University of Oxford, Oxford, OX2 6PN, UK.
⁵ UCB Pharma, 208 Bath Road, Slough, SL1 3WE, UK.
⁶ Key Laboratory for Organic Electronics & Information Displays (KLOEID), Institute of Advanced Materials (IAM) and School of Materials Science and Engineering, Nanjing University of Posts & Telecommunications Institution, 9 Wenyuan Road, Nanjing, 210046, China. [email protected].
⁷ Division of Physical Biology and Bioimaging Center, Shanghai Synchrotron Radiation Facility, CAS Key Laboratory of Interfacial Physics and Technology, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai, 201800, China. [email protected].

PMID: 27194406
DOI: 10.1002/anie.201512022

Abstract

The precise functionalization of self-assembled nanostructures with spatial and stereocontrol is a major objective of nanotechnology and holds great promise for many applications. Herein, the nanoscale addressability of DNA origami was exploited to develop a precise copy-machine-like platform that can transfer two-dimensional oligonucleotide patterns onto the surface of gold nanoparticles (AuNPs) through a deliberately designed toehold-initiated DNA displacement reaction. This strategy of DNA-origami-based nanoimprinting lithography (DONIL) demonstrates high precision in controlling the valence and valence angles of AuNPs. These DNA-decorated AuNPs act as precursors in the construction of discrete AuNP clusters with desired chirality.

Keywords: DNA nanotechnology; gold; nanoimprinting lithography; nanoparticles; self-assembly.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Bioprinting / methods*
DNA / chemistry*
Gold / chemistry
Metal Nanoparticles / chemistry
Metal Nanoparticles / ultrastructure
Nanostructures / chemistry*
Nanostructures / ultrastructure
Nanotechnology / methods*
Oligonucleotides / chemistry*

Substances

Oligonucleotides
Gold
DNA