Tcf1 and Lef1 pack their own HDAC

Charles P Ng; Dan R Littman

doi:10.1038/ni.3469

Tcf1 and Lef1 pack their own HDAC

Nat Immunol. 2016 May 19;17(6):615-6. doi: 10.1038/ni.3469.

Authors

Charles P Ng¹, Dan R Littman²

Affiliations

¹ The Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine, New York, New York, USA.
² The Kimmel Center for Biology and Medicine of the Skirball Institute and the Howard Hughes Medical Institute, New York University School of Medicine, New York, New York, USA.

PMID: 27196513
PMCID: PMC5675014
DOI: 10.1038/ni.3469

Abstract

The transcription factors Tcf1 and Lef1 have intrinsic histone-deacetylase activity that is required for the repression of CD4⁺ T cell-lineage genes in CD8⁺ T cells.

Publication types

Comment

MeSH terms

Hepatocyte Nuclear Factor 1-alpha*
Humans
Lymphoid Enhancer-Binding Factor 1*

Substances

Hepatocyte Nuclear Factor 1-alpha
Lymphoid Enhancer-Binding Factor 1

Grants and funding

T32 GM007308/GM/NIGMS NIH HHS/United States