Linking Nucleoporins, Mitosis, and Colon Cancer

Richard W Wong; Maximiliano D'Angelo

doi:10.1016/j.chembiol.2016.05.004

Linking Nucleoporins, Mitosis, and Colon Cancer

Cell Chem Biol. 2016 May 19;23(5):537-539. doi: 10.1016/j.chembiol.2016.05.004.

Authors

Richard W Wong¹, Maximiliano D'Angelo²

Affiliations

¹ Cell-Bionomics Research Unit, Innovative Integrated Bio-Research Core, Institute for Frontier Science Initiative, Bio-AFM Frontier Research Center, and Laboratory of Molecular Cellular Biology, Kanazawa University, Kakuma-machi, Kanazawa 920-1192, Japan. Electronic address: [email protected].
² Development, Aging, and Regeneration Program, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037, USA. Electronic address: [email protected].

Abstract

Suppression of a nuclear pore protein Nup358/RanBP2 is linked to mitotic cell death, but the clinical relevance of this link is unknown. In a recent issue of Cell, Vecchione et al. (2016) show that in approximately 10% of BRAF-like colorectal cancer (CC) patients, Nup358/RanBP2 is critical for survival. Treatment with vinorelbine, a microtubule-depolymerizing drug that inhibits mitosis, might be a potential treatment for these CCs.

Publication types

Comment

MeSH terms

Colonic Neoplasms*
Humans
Microtubules
Mitosis
Nuclear Pore Complex Proteins / genetics*

Substances

Nuclear Pore Complex Proteins

Grants and funding

R01 AR065083/AR/NIAMS NIH HHS/United States