Antibiotic-Resistant Infections and Treatment Challenges in the Immunocompromised Host

Infect Dis Clin North Am. 2016 Jun;30(2):465-489. doi: 10.1016/j.idc.2016.02.008.

Abstract

This article reviews antibiotic resistance and treatment of bacterial infections in the growing number of patients who are immunocompromised: solid organ transplant recipients, the neutropenic host, and persons with human immunodeficiency virus and AIDS. Specific mechanisms of resistance in both gram-negative and gram-positive bacteria, as well as newer treatment options are addressed elsewhere, and are only briefly discussed in the context of the immunocompromised host.

Keywords: HIV/AIDS; Immunocompromise; Infection; MDRO; Organ transplant recipients.

Publication types

  • Review

MeSH terms

  • Anti-Bacterial Agents* / administration & dosage
  • Anti-Bacterial Agents* / pharmacology
  • Anti-Bacterial Agents* / therapeutic use
  • Bacteria / drug effects
  • Bacteria / pathogenicity
  • Bacterial Infections* / drug therapy
  • Bacterial Infections* / microbiology
  • Drug Resistance, Multiple, Bacterial*
  • HIV Infections
  • Humans
  • Immunocompromised Host*
  • Transplant Recipients

Substances

  • Anti-Bacterial Agents