1 Haemophilia Centre and Haemostasis Unit, Department of Haematology, Royal Free Hospital, London NW3 2QG, †Haematology Department, Lewisham NHS Trust Hospital, London SE13 6LH, UK,Haematology Department, Lewisham NHS Trust Hospital, London SE13 6LH, UK,Oxford Haemophilia Centre, The Churchill, Headington, Oxford OX3 7LJ, UK.