Inhibition of precursor B-cell malignancy progression by toll-like receptor ligand-induced immune responses

M Fidanza; A E Seif; A DeMicco; N Rolf; S Jo; B Yin; Y Li; D M Barrett; J Duque-Afonso; M L Cleary; C H Bassing; S A Grupp; G S D Reid

doi:10.1038/leu.2016.152

Inhibition of precursor B-cell malignancy progression by toll-like receptor ligand-induced immune responses

Leukemia. 2016 Oct;30(10):2116-2119. doi: 10.1038/leu.2016.152. Epub 2016 May 25.

Authors

M Fidanza¹, A E Seif^{2

3

4}, A DeMicco^{2

4

5}, N Rolf^{1

6}, S Jo¹, B Yin^{2

4

5}, Y Li^{2

3

7}, D M Barrett^{2

3}, J Duque-Afonso⁸, M L Cleary⁸, C H Bassing^{2

4

5}, S A Grupp^{2

3

4}, G S D Reid^{1

6}

Affiliations

¹ Michael Cuccione Childhood Cancer Research Program, Child and Family Research Institute, Vancouver, British Columbia, Canada.
² Center for Childhood Cancer Research, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.
³ Department of Pediatrics, Division of Oncology, University of Pennsylvania, Philadelphia, PA, USA.
⁴ Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, PA, USA.
⁵ Department of Pathology and Laboratory Medicine, Division of Cancer Pathobiology, University of Pennsylvania, Philadelphia, PA, USA.
⁶ Department of Pediatrics, University of British Columbia, Vancouver, British Columbia, Canada.
⁷ Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, PA, USA.
⁸ Department of Pathology, School of Medicine, Stanford University, Stanford, CA, USA.

No abstract available

Publication types

Letter
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

MeSH terms

Animals
Basic Helix-Loop-Helix Transcription Factors / genetics
Core Binding Factor Alpha 2 Subunit / metabolism
Disease Progression
ETS Translocation Variant 6 Protein
Gene Expression Regulation, Leukemic*
Humans
Immune System
Inflammation
Ligands
Mice
Mice, Transgenic
Neutralization Tests
PAX5 Transcription Factor / metabolism
Phenotype
Pre-B-Cell Leukemia Transcription Factor 1 / genetics
Precursor Cell Lymphoblastic Leukemia-Lymphoma / immunology*
Precursor Cell Lymphoblastic Leukemia-Lymphoma / metabolism*
Precursor Cells, B-Lymphoid / immunology
Precursor Cells, B-Lymphoid / metabolism*
Proto-Oncogene Proteins c-ets / metabolism
Repressor Proteins / metabolism
Toll-Like Receptors / metabolism*

Substances

Basic Helix-Loop-Helix Transcription Factors
Core Binding Factor Alpha 2 Subunit
Ligands
PAX5 Transcription Factor
Pax5 protein, mouse
Pbx1 protein, mouse
Pre-B-Cell Leukemia Transcription Factor 1
Proto-Oncogene Proteins c-ets
Repressor Proteins
Runx1 protein, mouse
Tcf3 protein, mouse
Toll-Like Receptors

Publication types

MeSH terms

Substances

Grants and funding