Effect of chronic morphine administration on circulating dendritic cells in SIV-infected rhesus macaques

J Neuroimmunol. 2016 Jun 15:295-296:30-40. doi: 10.1016/j.jneuroim.2016.04.007. Epub 2016 Apr 16.

Abstract

We studied the effect of chronic morphine administration on the circulating dendritic cell population dynamics associated with SIV infection using rhesus macaques. Animals were either first infected with SIV and then given chronic morphine, or visa versa. SIV infection increased the numbers of myeloid DCs (mDCs), but morphine treatment attenuated this mDC expansion. In contrast, morphine increased the numbers of plasmacytoid DCs (pDCs) in SIV-infected animals. Finally, chronic morphine administration (no SIV) transiently increased the numbers of circulating pDCs. These results show that chronic morphine induces a significant alteration in the available circulating levels of critical antigen-presenting cells.

Keywords: CD83; Dendritic cells; Morphine; Myeloid; Plasmacytoid; SIV.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Analysis of Variance
  • Animals
  • Cell Count
  • Cytokines / metabolism
  • Dendritic Cells / drug effects*
  • Dendritic Cells / metabolism
  • Disease Models, Animal
  • Drug Administration Schedule
  • Female
  • Flow Cytometry
  • HIV Infections / pathology*
  • HIV Infections / veterinary
  • Macaca mulatta
  • Male
  • Morphine / pharmacology*
  • Myeloid Cells / drug effects
  • Myeloid Cells / metabolism
  • Narcotics / pharmacology*
  • Time Factors

Substances

  • Cytokines
  • Narcotics
  • Morphine