Prosthetic Vascular Graft Infections: Bacterial Cultures from Negative-Pressure-Wound-Therapy Foams Do Not Improve Diagnostics

Alexandra U Scherrer; Guido Bloemberg; Reinhard Zbinden; Annelies S Zinkernagel; Claudio Fuchs; Sandra Frauenfelder; Zoran Rancic; Dieter Mayer; Barbara Hasse; VASGRA Cohort

doi:10.1128/JCM.01102-16

Prosthetic Vascular Graft Infections: Bacterial Cultures from Negative-Pressure-Wound-Therapy Foams Do Not Improve Diagnostics

J Clin Microbiol. 2016 Aug;54(8):2190-3. doi: 10.1128/JCM.01102-16. Epub 2016 Jun 1.

Authors

Alexandra U Scherrer¹, Guido Bloemberg², Reinhard Zbinden², Annelies S Zinkernagel³, Claudio Fuchs³, Sandra Frauenfelder³, Zoran Rancic⁴, Dieter Mayer⁴, Barbara Hasse³; VASGRA Cohort

Affiliations

¹ Division of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, University of Zurich, Zurich, Switzerland [email protected].
² Institute of Medical Microbiology, University of Zurich, Zurich, Switzerland.
³ Division of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
⁴ Clinic for Cardiovascular Surgery, University Hospital Zurich, University of Zurich, Zurich, Switzerland.

Abstract

We analyzed the diagnostic value of microorganisms cultured from negative-pressure-wound-therapy (NPWT) foam samples compared to that of microorganisms cultured from deep tissue samples from patients with vascular graft infections. The sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) were 58%, 86%, 81%, and 66%, respectively. The diagnostic value of microbiological cultures from NPWT foams was poor.

Publication types

Evaluation Study

MeSH terms

Adult
Aged
Aged, 80 and over
Bacteria / isolation & purification*
Bacteriological Techniques / methods*
Exudates and Transudates / microbiology*
Female
Humans
Male
Middle Aged
Negative-Pressure Wound Therapy*
Predictive Value of Tests
Prosthesis-Related Infections / diagnosis*
Prosthesis-Related Infections / therapy*
Sensitivity and Specificity
Specimen Handling / methods*
Vascular Grafting

Grants and funding

The funders had no role in study design, data collection and interpretation, or the decision to submit the work for publication.