CD4(+) T cells in patients with chronic inflammatory rheumatic disorders show distinct levels of exhaustion

J Allergy Clin Immunol. 2016 Aug;138(2):586-589.e10. doi: 10.1016/j.jaci.2016.04.013. Epub 2016 Jun 2.

Authors

Theresa Frenz¹, Elena Grabski¹, Daniela Buschjäger¹, Lea A I Vaas¹, Nina Burgdorf¹, Reinhold E Schmidt², Torsten Witte², Ulrich Kalinke³

Affiliations

¹ Institute for Experimental Infection Research, TWINCORE, Centre for Experimental and Clinical Infection Research, a joint venture between the Helmholtz Centre for Infection Research and the Hannover Medical School, Hannover, Germany.
² Clinic for Immunology and Rheumatology, Hannover Medical School, Hannover, Germany.
³ Institute for Experimental Infection Research, TWINCORE, Centre for Experimental and Clinical Infection Research, a joint venture between the Helmholtz Centre for Infection Research and the Hannover Medical School, Hannover, Germany. Electronic address: [email protected].

PMID: 27264455
DOI: 10.1016/j.jaci.2016.04.013

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Arthritis, Rheumatoid / immunology
CD4-Positive T-Lymphocytes / immunology*
CTLA-4 Antigen / metabolism
Chronic Disease
Humans
Immune Tolerance
Inducible T-Cell Co-Stimulator Protein / metabolism
Interleukin-2 / metabolism
Lymphocyte Activation
Programmed Cell Death 1 Receptor / metabolism
Receptors, Antigen, T-Cell / metabolism
Rheumatic Diseases / immunology*
Spondylarthritis / immunology

Substances

CTLA-4 Antigen
CTLA4 protein, human
ICOS protein, human
IL2 protein, human
Inducible T-Cell Co-Stimulator Protein
Interleukin-2
PDCD1 protein, human
Programmed Cell Death 1 Receptor
Receptors, Antigen, T-Cell