Survival Outcomes in Early Stage Laryngeal Cancer

Uchechukwu C Megwalu; Haig Panossian

Survival Outcomes in Early Stage Laryngeal Cancer

Anticancer Res. 2016 Jun;36(6):2903-7.

Authors

Uchechukwu C Megwalu¹, Haig Panossian²

Affiliations

¹ Department of Otolaryngology - Head and Neck Surgery, Stanford University School of Medicine, Stanford, CA, U.S.A. [email protected].
² Department of Otolaryngology - Head and Neck Surgery, Icahn School of Medicine at Mount Sinai, New York, NY, U.S.A.

PMID: 27272804

Abstract

Aim: To evaluate survival outcomes of radiotherapy versus surgical resection in the treatment of early stage laryngeal cancer.

Patients and methods: Data was extracted from the Surveillance, Epidemiology, and End Results 18 Database. The cohort included 5,301 patients diagnosed with stages I and II laryngeal squamous cell carcinoma between 1992 and 2009, treated with either surgical therapy or radiotherapy.

Results: Patients who received surgical therapy had better overall survival (OS) than patients who received radiation therapy (p<0.001). The difference in OS between treatment groups remained after stratification by stage (p<0.001 for Stage I; p=0.03 for Stage II) and subsite (p<0.001). On multivariable analysis, the radiotherapy group had worse OS (hazard ratio (HR)=1.29).

Conclusion: Patients with early-stage laryngeal cancer treated with surgical therapy have better survival outcomes than patients treated with non-surgical therapy.

Keywords: SEER database; comparative effectiveness; laryngeal cancer; survival; therapy.

MeSH terms

Carcinoma, Squamous Cell / mortality*
Carcinoma, Squamous Cell / pathology
Carcinoma, Squamous Cell / therapy
Female
Head and Neck Neoplasms / mortality*
Head and Neck Neoplasms / pathology
Head and Neck Neoplasms / therapy
Humans
Laryngeal Neoplasms / mortality*
Laryngeal Neoplasms / pathology
Laryngeal Neoplasms / therapy
Male
Middle Aged
Neoplasm Staging
SEER Program
Squamous Cell Carcinoma of Head and Neck