Abstract
Progressive multifocal leukoencephalopathy (PML) is a viral demyelinating disease due to the reactivation of the JC virus (JCV), which usually occurs in the context of immunosuppression in HIV infection, malignancy, or in patients on disease modifying therapy for autoimmune diseases, such as multiple sclerosis (MS) and Crohn's disease. Notably, there is growing recognition that PML can occur in patients with transient immune dysfunction. Here, we present a case of a 55-year-old man without history of immunosuppression or evidence of ICL who was diagnosed with PML on brain biopsy. We will discuss the potential etiologies of mild and transient immunosuppression that can lead to PML with non-apparent immunosuppression.
Keywords:
Immunocompetent host; Progressive multifocal leukoencephalopathy.
MeSH terms
-
Brain / diagnostic imaging
-
Brain / immunology
-
Brain / pathology*
-
Brain / virology
-
Cognitive Dysfunction / diagnostic imaging
-
Cognitive Dysfunction / immunology
-
Cognitive Dysfunction / pathology*
-
Cognitive Dysfunction / virology
-
Diplopia / diagnostic imaging
-
Diplopia / immunology
-
Diplopia / pathology*
-
Diplopia / virology
-
Disease Progression
-
Fatal Outcome
-
Humans
-
Immunocompetence
-
JC Virus / immunology
-
JC Virus / isolation & purification
-
Leukoencephalopathy, Progressive Multifocal / diagnostic imaging
-
Leukoencephalopathy, Progressive Multifocal / immunology
-
Leukoencephalopathy, Progressive Multifocal / pathology*
-
Leukoencephalopathy, Progressive Multifocal / virology
-
Male
-
Middle Aged
-
Urinary Incontinence / diagnostic imaging
-
Urinary Incontinence / immunology
-
Urinary Incontinence / pathology*
-
Urinary Incontinence / virology
-
Vertigo / diagnostic imaging
-
Vertigo / immunology
-
Vertigo / pathology*
-
Vertigo / virology