68Ga-DOTATATE Breast Uptake and Expression in Breast Milk

Clin Nucl Med. 2016 Aug;41(8):654-5. doi: 10.1097/RLU.0000000000001266.

Abstract

The excretion of Ga-DOTA-Octreotate (DOTATATE) and related somatostatin analogues in breast milk has not been demonstrated. We report a case of a 34-year-old woman, 7 months postpartum and breastfeeding, who was referred for DOTATATE imaging after the diagnosis of appendiceal carcinoid and subsequent appendectomy. Prominent breast uptake was noted. A breast milk sample from the patient at 90 minutes postinjection was assayed in a gamma counter and shown to have a concentration of 5.6 Bq/g per MBq administered. The excretion of DOTATATE in breast milk is important to consider when providing radiation safety advice to breastfeeding patients.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Female
  • Humans
  • Mammary Glands, Human / metabolism*
  • Mammary Glands, Human / radiation effects
  • Milk, Human / radiation effects*
  • Organometallic Compounds / pharmacokinetics*
  • Positron-Emission Tomography / adverse effects*
  • Radiopharmaceuticals / pharmacokinetics*

Substances

  • Organometallic Compounds
  • Radiopharmaceuticals
  • gallium Ga 68 dotatate