Abstract
Dehydroascorbate is a by-product of copper-catalysed azide-alkyne click (CuAAC) reactions and also forms advanced glycation end products (AGEs) in tissues undergoing oxidative stress. Here we isolate and characterize an arginine-dehydroascorbate adduct formed during CuAAC reactions, investigate strategies for preventing its formation, and propose its biological relevance as an AGE.
MeSH terms
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Alkynes / chemistry*
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Arginine / chemistry*
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Azides / chemistry*
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Catalysis
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Click Chemistry
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Copper / chemistry*
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Dehydroascorbic Acid / chemical synthesis*
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Dehydroascorbic Acid / chemistry
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Glycation End Products, Advanced / chemical synthesis*
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Glycation End Products, Advanced / chemistry
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Molecular Structure
Substances
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Alkynes
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Azides
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Glycation End Products, Advanced
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Copper
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Arginine
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Dehydroascorbic Acid