Plasma membrane injury and repair is particularly prevalent in muscle cells. Here, we aimed to verify dysferlin, acid sphingomyelinase and transcriptional factor EB gene expression during Trypanosoma cruzi infection in vitro and in vivo. Our results showed that the parasite modulates gene expression of these proteins in a way dependent on the number of plasma membrane interacting parasites and in a rapamycin-sensitive manner.
Keywords: Acid sphingomyelinase; Dysferlin; Gene expression; Host interaction; Membrane repair; Transcriptional factor EB; Trypanosoma cruzi.
Copyright © 2016 Elsevier B.V. All rights reserved.